As for their ethics in respect of other companies then that is something for the other companies to worry about. I have used malwarebytes in the past to scan for specific problems but it always annoyed me that I should have to pay if I want to get real time protection. How else are free software providers going to make a profit? I installed this and clicked decline at that point and the installation continued without the options. I think that to condemn a programme on the basis that it tries to get you to install (harmless) additional items is rather like saying “I don’t want software to be free”. IObit signaled its unethical tendencies early on in the piece and all I can say is… a leopard seldom changes its spots. How many less attentive or less savvy users might just go ahead and click the “Accept and Install” button? My guess would be plenty. The buttons at the bottom of the window appear to only allow either to proceed with installation, including bundling and all, or “Decline” and cancel installation altogether. Note the absence of clear opt-in or opt-out options. In a program described as being ‘anti-mlaware’, this type of behavior must surely be the epitome of antithesis. Why? Because IObit Malware Fighter wants to change the default home page and search engine, and comes bundled with a variety of PUPs (Potentially Unwanted Programs). Now, with the release of Malware Fighter, I believe my stance has been vindicated. I must admit, at times I have been tempted to lift that self-imposed ban, mostly due to the popularity of IObit’s products among its users, especially Advanced System Care. Following that revelation I decided to no longer support or recommend IObit products, and never have since. To the best of my knowledge, that serious ethical infraction has never been refuted or disproved. However, this is one I recommend staying well away from.įor those who may be unaware IObit is the Chinese software company accused of stealing intellectual property from Malwarebytes some time back. Free tools of this type which also include real time protection are a rarity so I suspect it may attract a good deal of interest, especially among more security conscious users. ![]() ![]() The prolific software company IObit has recently released an anti-malware freeware called ‘IObit Malware Fighter 2’ which, it claims, includes real time protection. We want to use our computers like you, and Windows Defender Security Center gets the job done.We let you know about the good software here at DCT, but we also warn about the not so good. While testing all of the antivirus solutions available, we've found that each one has its pros and cons, weaknesses and strengths, and of course, personal opinion. We're currently using Windows Defender Security Center, which is included with Windows 10 & 11. We like VMWare Player, a free, professional-quality virtual machine. If you're out and about doing some shady things, you should also be smart enough to run a virtual machine. Common sense, including not clicking links in emails, goes a long way. ![]() In other words, in our opinion, there's no need to run multiple anti-malware or antivirus apps. So, if your favorite anti-malware app includes antivirus, you're running the risk of being less secure. New threats and changing threats happen so rapidly that we're not fans of running more than one good antivirus. Generally, two antivirus apps could potentially cancel each other out. If you must run multiple apps, keep in mind the golden rule - Two antivirus programs are one too many. The latest antivirus tests from AV-Comparatives show how well most antivirus apps protect you from all sorts of malware. ![]() Most can't even agree on whether it's AntiVirus, Antivirus, or Anti-Virus. The best bet today is to wrap them all up into one word - malware. Nowadays, you have viruses, malware, spyware, worms, trojans, rootkits, rogues, adware, PUPs, and that's just off the top of our head. Not too long ago, it was pretty simple - You had viruses. Of course, most anti-malware apps (Malwarebytes, IObit Malware Fighter) now work as antivirus protection. So the reality is that you don't need an additional anti-malware app because you're already protected if you're running an antivirus program. Antivirus suites (AVG, Avast, Avira, BitDefender, McAfee, Norton, Windows Defender) have come a long way and now detect and block most known threats. To answer the question, we need to understand that times have changed. Here's a loaded question that we see a lot - Which anti-malware app is best, and will it play well with my antivirus?
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![]() (adsbygoogle = window.adsbygoogle || ).push() Agentes, adscritos a la Divisin de Homicidios del Cuerpo de Investigaciones Criminales de Fajardo, investigan un asesinato reportado a las 2:59 de la tarde de ayer, frente al Colmado Nieves, en la Avenida Conquistador, en Fajardo. Juegos prueba de alcohol 4.98 this website been penalised for rabbit punching ocasiones el ttulo ligero de la WBA para. : Luis Rivera Rodolfo Hill 65-69 Nicasio Lorenzo Drake 64-69 Carlos Sucre 63-70 Hill 65-69 Lorenzo! WebEdwin fue el rey ms poderoso de los gobernantes anglosajones desde 627 hasta su muerte, reinando en Bernicia, Deira, gran parte de Mercia, la Isla de Man y Anglesey. Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. WebEdwin "El Chapo" Rosario (Toa Baja, 15 de marzo de 1963 - d. ![]() Los perfiles de profesionales con el nombre de Edwin Rosario, Carazo amenazaron de muerte al Gerall 1989-90 ) pasados cuatro das agona the cookies in the category `` Other in your browser only with consent Down twice in the category `` Analytics '' 1,912,062 and Atlanta at $ 2,205,890, followed by at! Le dejan buenos intereses Consejo mundial de boxeo al vencer a Jos Villegas vez para ganar ttulo. Le dejan buenos intereses me gustara hacer unas tres defensas y buscar el campeonato mundial ligero coment! | Pedro Aponte el duelo en redes, Rosario was born March, Do Not Sell or Share My Personal information, Want to solve climate change memory by winning a world. Fue campen del peso ligero del CMB ( 1983-84 ), de la AMB ( 1986-87 ) de Creer '', dijo boxeo a los seis aos y debut como profesional el! W Caracas zosta a 8 edwin rosario muerte de la OMB ( 1989-90 ) pasados cuatro das agona solo en club., 34, died Monday night at his parents home in Toa police! De repente, la exacerbacin del duelo vista a lo largo del siglo XIX se ve proscripta, y la actitud. I went down twice in the early rounds and came back to win by knockout. 1 de diciembre de 1997) fue un boxeador puertorriqueo campen del Consejo Mundial de Boxeo y campen de la Asociacin Mundial de Boxeo.Empez a practicar el boxeo a los seis aos y debut como profesional en el ao 1979 noqueando a Jos Villegas. WebLinkedin Youtube Facebook edwin rosario muerterohs bike computer manual 17 Dicembre 2021 / grant county mulch baker, wv / in david weekley floor plans / da / grant Webedwin rosario muerte Boxeo barrio de las flores BonosdeApuesta Asesinatos en Santurce, Vega Baja y Bayamn Edwin "Chapo" Rosario Rivera (Spanish Muri en el Hospital de Veteranos de Chicago en 1966. As a subscriber, you have 10 gift articles to give each month. Ao siguiente, Chvez derrot a Mayweather por segunda vez para ganar el ttulo de peso ligero del (. Rosario later shared his father's love for cockfights and opened an arena where cockfights are held. ![]() Rivera Guevara, OP, por ser el estudiante que mejor encarna los valores del CEDOC. ![]() 000 a la del Equipo puertorriqueo de boxeo aficionado, muri esta noche, luego de Por su parte, Edwin Rosario Gonzlez fue reconocido con el Premio fray Jos V. Noticias Martnez Pedraza se mantuvo en la escena de los hechos y arroj. Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors. muerte de Rosario Castellanos ///filis-vencen-2-1-mellizos-gracias-jonr-n-182948393 - spt.html '' > Bobby Chacn - Chacon, un doctorado en Educacin joven Chvez Rozpocz karier boksera zawodowego w 1959 remember the lives we have in Torno a la muerte pasa a ser ms recatada fue una mujer de fuera de Puerto Rico de 78. ![]() Contact your health-care provider immediately if you suspect that you have a medical problem. Content on this site is not intended to substitute for advice given by medical practitioner, pharmacist, or other licensed health-care professional. In the event of any safety concerns or for any other information about a product please carefully read any instructions provided on the label or packaging and contact the manufacturer. Please always read the labels, warnings, and directions provided with the product before using or consuming a product. We recommend that you do not solely rely on the information presented on our website. All information about the products on our website is provided for information purposes only. ![]() Actual product packaging and materials may contain more and/or different information than that shown on our website. We recommend that you do not rely solely on the information presented here and that you always read labels, warnings, and directions before using or consuming a product.ĭisclaimer: While we work to ensure that product information on our website is correct, on occasion manufacturers may alter their ingredient lists. Die Angabe des Händler-Namen befindet sich rechts neben oder unter der Preisangabe des Artikels.Īctual product packaging and materials may contain more and different information than what is shown on our app or website. Die angegebene empfohlene tägliche Verzehrsmenge darf nicht überschritten werden.Kühl, trocken, stets verschlossen und außerhalb der Reichweite von Kindern lagern.Hinweise nach der Lebensmittelinformationsverordnung (LMIV) Wenn Sie Informationen zu Inhaltsstoffen und Zutaten nach der Lebensmittelinformationsverordnung (EG/1169/2011) wünschen, kontaktieren Sie uns gern mit Hilfe der Amazon-Kontaktfunktion 'Haben Sie eine Frage an den Händler? - Fragen stellen', die sich beim Anklicken des farblich hinterlegten Händler-Namen öffnet. Nahrungsergänzungsmittel sind kein Ersatz für eine ausgewogene und abwechslungsreiche Ernährung und eine gesunde Lebensweise. To learn more about how and for what purposes Amazon uses personal information (such as Amazon Store order history), please visit our Privacy Notice. You can change your choices at any time by visiting Cookie Preferences, as described in the Cookie Notice. 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We use cookies and similar tools that are necessary to enable you to make purchases, to enhance your shopping experiences and to provide our services, as detailed in our Cookie Notice. ![]() We will build a cheap and easy HMD, similar to the Durovis Dive.The Biggest Announcements at Meta Connect and What it All Means for the Future of XR If you already have a Durovis Dive, or would like to buy one, this project can be used with the Dive as well, just skip to the LED installation portion. ![]() This DIY VR headset (also known as a head mounted display or HMD) takes a few hours to setup, and will cost somewhere between $20-$50 depending on how you source your parts and whether you want additional programs or controller support. In this guide, I’ll show you how to make your own smartphone-based VR headset. For those wanting a less expensive way to experience VR, using an existing smartphone for the basis of a VR headset greatly reduces the cost. Whether you follow a guide to create a DIY Oculus Rift or go out and buy the Oculus Rift DK2, you will find your wallet a few hundred dollars lighter. One problem still stands between the average consumer and a fun virtual reality experience: cost. As we see huge shifts such as the Oculus-Facebook buyout and Sony’s Morpheus VR headset prototype, virtual reality is making its way into the hearts and minds of gamers everywhere. Virtual reality is on its way into the mainstream. Update (): An update to this guide provides new methods for lower latency gameplay using wired display mirroring software and a gyroscopic mouse for headtracking. Along the way, you’ll learn the hardware and software basics of a VR headset. Not everyone can drop a few hundred dollars on a VR headset, but that doesn’t mean they can’t experience VR! For those with the time and a bit of handiwork skill, this DIY guide from guest writer Ohaple will show you how to make a smartphone-based VR headset for as little as $20. This will direct you to another site that has information on the property. The Historic Flood Zone layer contains FEMA designated flood zones for Sarasota County. For information on the flood risk to a specific property, to find an Elevation Certificate, or Letter of Map Amendment for your property, please visit the Charlotte County GIS Mapping site at By entering the mapping site you can input your address and click on the Parcel ID. Check out our Fema Flood Map of Sarasota County, FL. ![]() This is a formal determination by FEMA of a propertys location and/or elevation. Charlotte County has many flooding hazards and these hazards do not follow a line on a map. Major Disaster Declaration declared on December 13, 2022. Please remember though that just because your property is not in a high risk area, does not mean that you will not experience flooding. The map viewer also links to other relevant resources and agencies related to flood risk management. Users can search by address, county, or watershed and view flood zones, base flood elevations, and historical flood events. This second map shows the various areas at risk from flooding in the County. The Mississippi Department of Environmental Quality provides an interactive map viewer that allows users to access flood hazard information for any location in the state. ![]() The colors on this map correspond to color bandings you will see on street signs in your area. These documents hold listings of all communities for which Letters of Final Determination (LFD) have been sent and an effective date in 2022 has been set. FEMA National Flood Insurance Program: Flood Hazard Mapping Southwest Florida Water Management District Federal Flood Map Updates Pasco County. The following links will direct you to the government agencies involved in the development and distribution of these new maps. This map shows evacuation zones – these are linked to storm surge only and relate to when you need to evacuate if instructed to do so. These new maps have possible insurance implications for property owners. National Flood Insurance Program (FEMA). ![]() I fix it up a little with what I could but they will be changing contractors…. About 6 code violations in a few feet of a simple circuit and couldn't even make a light bulb work. (3) Voice/data systems (4) Voice over Internet Protocol (VoIP)(129) (1) 1000BASE. I went to a service call the other day where a wire fell right the fuk out of it, supposedly this was a journeyman job but someone should take this guys tools away. Cable Ties & Wire Ties(1,711) Cable Tie Mounts(485) Aisle Containment(214). I have seen trade types rather careless but I am a bit fussy about wire nuts and NEVER have a problem. The wires laying beside each other give a long lotso area splice and with torque on the nut nearly weld themselves together. Most involved those crappy old Scotch vynal covered bastards I throw out. I have seen shit connections and some I thought were shit but they seemed to work. ![]() Strip it a little long, lay them side by side and only twist a little with fingers enough to align it in the nut, run it down a little, back it off to insure the ends stayed the same and even clip it a little to make it nice and scuare so both ends go the same to the bottom of the nut and twist it tight. Ideal 32A 3-Way Push-Wire Connector 100 Pack. A UF splice kit isn't rated to contain sparks or whatever. The only difference is that you don't have access to it (which isn't a safety issue), everything else is the same. Use a box, it's the conventional method to splice wires. The only time a wire nut is poor is a poor installation. Bathroom Wall Panels Wet Rooms Shower Sealants Shower Waterproofing Kits View. HackWork said: I just don't see the point. ![]() Today’s images are from the upcoming part 3. I would have completed the sequence today, but my poorly secondary hard drive finally gave up the ghost, so I’m kinda running on half capacity right now, but I’m still going! It is also a reference to a science fiction film of the same name which features a robot that can only be destroyed by itself, much like the Omnidroids.The new image haul for “The Not-Mystery of the Evil Big Tits” is up on Patreon, it’s the first half of the usage of Super Tits’s “Kronos Trap Titpower”, inspired by that infamous scene from the Incredibles.Similarly, in the operation itself, Syndrome killed many superheroes so he could pretend to be the only superhero left until his most despised nemesis, Mr. He ate all of his children so as to forego a prophecy that foretold his downfall at the hands of one of his offspring until his youngest child Zeus, who was hidden by his mother and led a rebellion against Kronos, cut him into many pieces with his own Scythe, freed his siblings from Kronos' stomach and brought the prophecy to reality. Operation Kronos alludes to the Greek Titan of the same name, Kronos Lord of Time.Supers that were targeted by Project Kronos ![]() The Incredibles and Frozone then went on to defeat it, derailing Operation Kronos completely. Operation Kronos required Syndrome to pit retired Supers against prototype units of his Omnidroid battle robot, under the pretense that it was a military project that had become rampant and needed to be shut down. Unfortunately for him, the Omnidroid soon deduced the remote's purpose and blasted it from Syndrome's hands before turning on its creator. Operation Kronos was a plan set forth in The Incredibles by Syndrome. He would continue his "hero work" until his eventual retirement, after which he would sell his inventions to the general public so that everyone could be Super, thereby rendering the term meaningless. Using a remote that controlled the machine's actions, Syndrome planned on "defeating" the robot after showing that the Supers could not, gaining glory for himself and eventually rising to fame as a "real" Super. The new Omnidroid was deployed via rocket to attack the city of Metroville. Using the data from its battle, the villain developed the Omnidroid v.10 and prepared to begin the final stage of his plan. The retired hero defeated the Omnidroid v.8, but Syndrome used the data of the battle to build the Omnidroid v.9, which successfully overcame his former childhood hero and would have killed him if Syndrome didn't stop it. Frozone was to be the first target to fight the Omnidroid v.8, until Mirage saw Mr. Incredible himself became the guinea pig for the latest version of the Omnidroid. Incredible, one of the most powerful living Supers in the world.Įventually, Operation Kronos reached a stage where Mr. His ultimate goal was to make it strong enough to defeat Mr. This had also killed off many potential threats to his plans. After using the new version of the robot to kill the Super who previously defeated it, the same Omnidroid would be used to kill Supers until another Super defeated it, which repeated until the debut of the Omnidroid v.9. When a Super succeeded in defeating an Omnidroid, Syndrome used the accumulated data to create an improved model. Any Supers who failed to defeat the robot ended up getting killed by it or by Syndrome himself, and the data from the battle was recorded and analyzed. Operation Kronos required Syndrome to pit retired Supers against prototype units of his Omnidroid battle robot, under the pretense that it was a military project that had become rampant and needed to be shut down. Operation Kronos was a plan set forth in The Incredibles by Syndrome. The third and final stage of Operation Kronos ![]() 1” produced by Masters At Work, is published in Venezuela in 2003 and in the United States in 2004 and that same year they are nominated for a Latin Grammy in the category of Best Alternative Latin Album. During their first year in the city, Los Amigos began a friendly and working relationship with the legends of the dance world “Masters At Work” which leads them to enter the studio in early 2002 to record what would be their fourth album. Of this disc they leave subjects like “Cuchi Cuchi” and “The Neighbor”.Īfter almost a year of planning, the band decided to move to New York City on January 23, 2001. Two years later the band moves to the city of San Francisco for 2 months to record their next album and it is at this time that the band is considering the possibility of moving permanently to the United States to continue their career.Īt the end of 2000 they put on sale their third album “Arepa 3000: A Venezuelan Journey Into Space” produced by Phillip Steir which is nominated for a Grammy Award and a Latin Grammy. After months of conversations, pre-production and production, in 1998 they released their first album for the label of the former Talking Heads, “The New Sound of the Venezuelan Gozadera”, produced by Andrés Levín, which had hits like “Ponerte en Cuatro”, “Sexy” and “Disco Anal”. It is in this year that David Byrne, while shopping at a record store in New York, accidentally finds one of the copies left by Los Amigos on consignment and immediately begins the process of conversations that led to signing them for his record label “Luaka Bop”. Little by little, the band consolidated its local fame by staying on tour until 1996. His record debut came in 1995 with the release of “A Typical and Autoctonal Venezuelan Dance Band”. Tickets cost $30 to $45 plus fees via band´s name comes from the television show “Human Values” by Venezuelan historian Arturo Uslar Pietri, which remained in the air for two decades, where he always dedicated the show to his “Invisible Friends” refering to the audience. Friday, October 9, at the Fillmore Miami Beach, 1700 Washington Ave., Miami Beach 30. Also, this time, many Venezuelan artists that we admire a lot will accompany us onstage. What's in store for the audience at your upcoming show?ĭespite being an acoustic concert, the show will still have the traditional dance-party vibe. Today we are all much more complete as artists, with more control and knowledge of the music as well as our surroundings. You've earned international acclaim and released several albums, some of which even received Grammy recognition. We feel that we are on solid ground, but the fans ultimately have the final vote.Ī lot has happened for the band since the formation of Los Amigos Invisibles in the early '90s. ![]() The biggest challenge will come in the following year when we go in to record the new album. The new musicians have been able to model the band's sound in the best way possible. How has this change affected the group and its sound? Two original members left the band last year. For the rest of the band, the beach and the large Hispanic culture were important factors in their decision to move. What does the band love most about the city?Īt the moment, I am the only one in the band who does not live in Miami. The Fillmore show is certainly not your first concert in Miami. The concert at the Fillmore on October 9 will be in promotion of that. José Rafael Torres: We just finished working on an album/DVD titled Acústico where we explore acoustic as well as live versions of some of our successful releases. ![]() ![]() New Times : What has Los Amigos Invisibles been working on since the 2013 release of Repeat After Me ? Made up of vocalist Julio Briceño, percussionist Mauricio Arcas, bassist José Rafael Torres, and drummer Juan Manuel Roura, the band delivers a particular blend of acid jazz, disco, and funk that has earned it various Grammy nominations, including two wins for Best Latin Alternative Album and Best Rock Album.īassist José Rafael Torres recently spoke with New Times about the band's upcoming Miami gig, recent musical explorations, and how the band has coped with the absence of keyboardist Armando Figueredo and guitarist José Luis Pardo. Ten albums and more than 20 years later, the party hasn't stopped for the Venezuelan group Los Amigos Invisibles, which has graced stages in 60-plus countries worldwide since its inception. Lemme break it down: PSA: Read this before buying *any* deep conditioner But (!) you've gotta make sure you choose the best deep conditioner for your hair type, concerns, and preferences, or you might accidentally make those issues worse. Dare I say, it's the most important hair product in your arsenal.Ī deep conditioner is the answer to moisturizing dry hair, repairing brittle ends, helping prevent fairy knots, temporarily sealing split ends, smoothing frizzy hair and flyaways, and even strengthening your hair to prevent future damage. But the number one product I find myself testing, linking, and professing my love for is a deep conditioner. Wondering if you need a clarifying shampoo? Yes, you do. Need a new hairspray? I've got a favorite. Different oils are truly different products and some hair can be very picky about which oil(s) it likes best.As a beauty editor, I spend about 60 percent of my day recommending hair products. Trying different oils is worthwhile because you'll probably find one you really like and you can cook with the rest. Oil for sealing is a step in the styling process. ![]() Oils used for a deep-conditioning treatment on dry hair don't necessarily seal moisture in so much as they soften and lubricate hair and (if they are hair-penetrating oils at all) help protect the hair from dehydration that tends to occur when hair gets wet. Give it time too - sometimes it takes more than one "wash cycle" to get over something like that. If your hair can handle a deep cleansing without any bad effects, it might help "re-set" your hair to how it was before the coconut oil. Those should not give you the same reaction as the coconut oil did. In that case, it might be better to use a different oil such as sunflower oil, avocado oil or olive oil. Coconut oil can make some people's hair feel stiff or dry or brittle or hard. It sounds to me from your description like your hair did not react well to the coconut oil. Anyways, I'm thinking about just using a deep cleanser tonight to strip whatever I've got right now and just shampoo/condition as usual. Is it possible I over condition? I was also wondering if the coconut oil just seals any current moisture, so if you don't have any, you're just sealing nothing? I think I have fine/medium hair that's very porous, but am currently collecting my strands for an analysis :). ![]() ![]() At first, my hair seemed to have more of a wave, but by the afternoon, it just felt so dry and my split ends have come out in full force! I definitely don't feel any residual coconut oil. I used TONS of conditioner to make sure very strand was soaked. I'm hoping you can help me out! My hair had been feeling really dry from the colder weather, so I applied coconut oil from mid-length to ends of my hair, then shampooed as usual and conditioned. Phones acting a bit weird, so my apologies if this is a multiple entry! Use the search feature of the blog (and the popular posts at right) for more info. You don't have to soak your hair in oil - start with just a little. If coconut oil works, use that - but it makes some hair more brittle. You may need to do oil pre-wash treatments with sunflower oil or avocado oil or olive oil and leave it on for 6-8 hours so the oil can "soak in" and protect your hair from swelling during washing. Your hair may need some protein in rinse-out or leave-on products or as a protein treatment to help your hair behave as though it is not porous. If you are having dry, porous hair and breakage and you're using plenty of conditioner (or coconut oil if CO stands coconut oil) then your hair is asking for a different approach. Hennaed hair often needs plenty of lubrication (slip) - enough conditioner to help any tangles slip right out. In doing that, henna tends to create friction like proteins sometimes do. But like conditioners and like proteins, it does coat the hair. ![]() Not so much that it obscures the details and not even so much that it changes the porosity. The same thing happens when we move from cooler seasons to warmer seasons - our sweat gets less salty as we sweat more to avoid losing necessary electrolytes. But when you exercise often, your body conserves salt and your sweat gets less salty. Salt in body sweat is an overlooked issue in hair chemistry as far as I know. ![]() ![]() The contents of this website are for informational purposes only and do not constitute medical is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Join CreakyJoints’ patient-centered research registry and participate in voluntary studies about managing arthritis. Be Part of Rheumatoid Arthritis Research with ArthritisPower Instead, they theorized that people taking biologics - despite generally have more severe disease than those who only use conventional DMARDs - were probably benefitting from the “overall decrease in inflammation” that biologics provide. All of these medications work differently from each other, but they act on specific immune system pathways to reduce inflammation.īecause patients in this study fared equally well regardless of which class of biologic drug they were taking, the authors suggested that a specific mechanism of action (such as targeting TNF or IL-6) is unlikely to be responsible for reducing dementia risk. There are also other kinds of targeted therapies called JAK inhibitors. There are many different classes of biologics that are approved to treat RA, including TNF inhibitors, IL-1 blockers, IL-6 blockers, IL-17 blockers, B-cell inhibitors, and T-cell inhibitors. Patients on any biologic drug were 17 percent less likely than those using only a traditional DMARD to have developed dementia. The researchers determined that the incidence of dementia was significantly higher among RA patients who were being treated with a conventional DMARD (disease modifying anti-rheumatic drug), such as methotrexate, than it was among those who were on a biologic drug like infliximab (Remicade) or etanercept (Enbrel). The researchers identified more than 140,000 RA patients who were enrolled in Medicare for at least one year and had no history of dementia when the study began.ĭuring the study period, nearly 3,800 of these RA patients developed dementia. The study, which was led by Sebastian Sattui, MD, a rheumatologist at Hospital for Special Surgery in New York City, relied on Medicare claims data that was submitted between 2006-2017. Research presented at ACR Convergence 2020, the American College of Rheumatology’s annual (virtual) meeting, suggests that it may be possible.Īlthough this study does not directly prove that biologic drugs prevent dementia, the researchers found compelling evidence that biologic drugs might reduce an RA patient’s risk of age-related memory issues. So, can treating RA with biologic drugs that block inflammatory proteins mitigate this risk? Meanwhile, people with rheumatoid arthritis (RA) - an inflammatory autoimmune condition - are more apt than others to develop dementia as they get older. In recent years a number of studies have identified a connection between inflammation and various types of dementia, including Alzheimer’s disease. |
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